Open Evidence Captures Doctors’ Collective Wisdom with AI ft. Zachary Ziegler

Open Evidence CTO Zachary Ziegler demos how 25% of US physicians use the platform daily, and previews aggregating collective clinical wisdom from millions of doctors.

• Open Evidence reached 25% of all US practicing physicians as monthly active users within 12 months.
• The average user opens the platform every single day, signaling deep workflow integration.
• A physician used it mid-flight to assess immunosuppression risk in a cancer patient with suspected chickenpox, avoiding an emergency landing.
• Enzalutamide (Xtandi) for prostate cancer causes only moderate immunosuppression — a nuanced finding that changed the treatment urgency calculus.
• Ziegler argues every patient is a long-tail edge case; no single doctor can hold all relevant context in their head.
• Open Evidence is now building a system to encode and aggregate tacit clinical knowledge from millions of practicing physicians — knowledge that has never been written down.
• The first answer augmented by aggregated GI specialist wisdom was demoed publicly for the first time at this event.

2025-05-12 · Watch on YouTube