Where Enterprises are Actually Adopting AI — Kimberly Tan

Summary

A16z finds ~29% of the Fortune 500 and 19% of Global 2000 are now live, paying AI startup customers — remarkable penetration in just 3 years since ChatGPT. The highest-value use cases are coding (dominant by an order of magnitude), customer support, and search, with tech, legal, and healthcare leading adoption. Key success factors: text-based work, clear ROI, verifiable outputs, and natural human-in-the-loop workflows. Biggest opportunities lie in vertical specialization, emerging domains like accounting, and infrastructure around computer use and long-horizon agents.

Source: Andreessen Horowitz Date: 2026-04

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